Peroxisome Proliferator-Activated Receptor (PPAR) α and PPARβ/δ, but not PPARγ, Modulate the Expression of Genes Involved in Cardiac Lipid Metabolism

J. Gilde, Andries; A. J. M. van der Lee, Karin; H. M. Willemsen, P.; Chinetti, Giulia; R. van der Leij, Feike; J. Vusse, Ger; Staels, Bart; van Bilsen, Marc

doi:10.1161/01.res.0000060700.55247.7c

Public

Peroxisome Proliferator-Activated Receptor (PPAR) α and PPARβ/δ, but not PPARγ, Modulate the Expression of Genes Involved in Cardiac Lipid Metabolism

Published in Circulation Research • Mar 20, 2003

Authors:

Andries J. Gilde

Karin A. J. M. van der Lee

P. H. M. Willemsen

Abstract

Long-chain fatty acids (FA) coordinately induce the expression of a panel of genes involved in cellular FA metabolism in cardiac muscle cells, thereby promoting their own metabolism. These effects are likely to be mediated by peroxisome proliferator-activated receptors (PPARs). Whereas the significa...

Subject

Peroxisome proliferator-activated receptor

Lipid metabolism

Peroxisome

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