Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation

Tsutsumi, Yoshiaki; Matsubara, Hiroaki; Masaki, Hiroya; Kurihara, Hiroki; Murasawa, Satoshi; Takai, Shinji; Miyazaki, Mizuo; Nozawa, Yoshihisa; Ozono, Ryoji; Nakagawa, Keigo; Miwa, Takeshi; Kawada, Noritaka; Mori, Yasukiyo; Shibasaki, Yasunobu; Tanaka, Yohko; Fujiyama, Soichiro; Koyama, Yohko; Fujiyama, Atsuko; Takahashi, Hakuo; Iwasaka, Toshiji

doi:10.1172/jci7886

Public

Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation

Published in Journal of Clinical Investigation • Oct 1, 1999

Authors:

Yoshiaki Tsutsumi

Hiroaki Matsubara

Hiroya Masaki

Abstract

Angiotensin II (Ang II) is a potent vasopressor peptide that interacts with 2 major receptor isoforms - AT1 and AT2. Although blood pressure is increased in AT2 knockout mice, the underlying mechanisms remain undefined because of the low levels of expression of AT2 in the vasculature. Here we overex...

Subject

Icatibant

Bradykinin

Angiotensin II

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