HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

I. Swerdlow, Daniel; Preiss, David; Kuchenbaecker, Karoline; V. Holmes, Michael; Engmann, Jorgen; Shah, Tina; Sofat, Reecha; Stender, Stefan; Johnson, P.; A. Scott, Robert; Leusink, Maarten; Verweij, Niek; J. Sharp, Stephen; Guo, Yiran; Giambartolomei, Claudia; Lee Chung, Christina; Peasey, Anne; Amuzu, Antoinette; Li, KaWah; Palmen, Jutta; Howard, Philip; A. Cooper, Jackie; Drenos, Fotios; R Li, Yun; Lowe, Gordon; Gallacher, John; Stewart, Marlene; Tzoulaki, Ioanna; G. Buxbaum, Sarah; L. van der A, Daphne; G. Forouhi, Nita; Charlotte Onland‐Moret, N.; T. van der Schouw, Yvonne; B. Schnabel, Renate; A. Hubáček, Jaroslav; Kubínová, Růžena; Bacevičienė, Miglė; Tamošiūnas, Abdonas; Pająk, Andrzej; Topor-Madry, Romanvan; Stepaniak, Urszula; Malyutina, Sofia; Baldassarre, Damiano; Sennblad, Bengt; Tremoli, Elena; dé Fairé, Ulf; Veglia, Fabrizio; Ford, Ian; Wouter Jukema, J.; G. J. Westendorp, Rudi; J. de Borst, Gert; A. de Jong, Pim; Algra, Ale; Spiering, Wilko; H. Maitland‐van der Zee, Anke; H. Klungel, Olaf; de Boer, Anthonius; A. Doevendans, Pieter; B. Eaton, Charles; G. Robinson, Jennifer; Duggan, David; Kjekshus, John; R. Downs, John; M. Gotto, Antonio; Keech, Anthony; Marchioli, Roberto; Tognoni, Gianni; S. Sever, Peter; R Poulter, Neil; D. Waters, David; R. Pedersen, Terje; Amarenco, Pierre; Nakamura, Haruo; J.V. McMurray, John; Lewsey, James; I. Chasman, Daniel; M. Ridker, Paul; P. Maggioni, Aldo; Tavazzi, Luigi; K. Ray, Kausik; Rao Kondapally Seshasai, Sreenivasa; E. Manson, JoAnn; F. Price, Jackie; H. Whincup, Peter; Morris, Richard; A. Lawlor, Debbie; Davey Smith, George; Ben‐Shlomo, Yoav; J. Schreiner, Pamela; Fornage, Myriam; S. Siscovick, David; Cushman, Mary; Kumari, Meena; J Wareham, Nick; M. Monique Verschuren, W.; Redline, Susan; R. Patel, Sanjay; C. Whittaker, John; Hamsten, Anders; A. Delaney, Joseph; Dale, Caroline; R. Gaunt, Tom; Wong, Andrew; Kuh, Diana; Hardy, Rebecca; Kathiresan, Sekar; Almoguera Castillo, Berta; van der Harst, Pim; J. Brunner, Eric; Tybjærg‐Hansen, Anne; Marmot, Michael; M. Krauss, Ronald; Y. Tsai, Michael; Coresh, Josef; C. Hoogeveen, Ron; M. Psaty, Bruce; A. Lange, Leslie; Håkonarson, Håkon; Dudbridge, Frank; E. Humphries, Steve; J. Talmud, Philippa; Kivimäki, Mika; J. Timpson, Nicholas; Langenberg, Claudia; W. Asselbergs, Folkert; И. Воевода, М.; Bobák, Martin; Pikhart, Hynek; G. Wilson, James; P. Reiner, Alex; J. Keating, Brendan; D. Hingorani, Aroon; Sattar, Naveed

doi:10.1016/s0140-6736(14)61183-1

Public

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Published in The Lancet • Sep 24, 2014

Authors:

Daniel I. Swerdlow

David Preiss

Karoline Kuchenbaecker

Abstract

BACKGROUND: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. METHODS: We used single nucleotide polymorphisms in the HMGCR ge...

Subject

Type 2 diabetes

HMG-CoA reductase

Medicine

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