A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

M. Frayling, Timothy; J. Timpson, Nicholas; N. Weedon, Michael; Zeggini, Eleftheria; M. Freathy, Rachel; M. Lindgren, Cecilia; R. B. Perry, John; S. Elliott, Katherine; Lango Allen, Hana; W. Rayner, Nigel; M. Shields, Beverley; W. Harries, Lorna; C. Barrett, Jeffrey; Ellard, Sian; J. Groves, Christopher; Knight, Bridget; Patch, Ann‐Marie; R. Ness, Andrew; Ebrahim, Shah; A. Lawlor, Debbie; M. Ring, Susan; Ben‐Shlomo, Yoav; Järvelin, Marjo‐Riitta; Sovio, Ulla; J. Bennett, Amanda; Melzer, David; Ferrucci, Luigi; J. F. Loos, Ruth; Barroso, Inês; J. Wareham, Nicholas; Karpe, Fredrik; R. Owen, Katharine; R. Cardon, Lon; Walker, Mark; A. Hitman, G.; N. A. Palmer, Colin; S. F. Doney, Alex; D. Morris, Andrew; Davey Smith, George; T. Hattersley, Andrew; I. McCarthy, Mark

doi:10.1126/science.1141634

Public

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Published in Science • Apr 12, 2007

Authors:

Timothy M. Frayling

Nicholas J. Timpson

Michael N. Weedon

Abstract

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associat...

Subject

Obesity

Body mass index

FTO gene

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