Class III beta-tubulin expression predicts prostate tumor aggressiveness and patient response to docetaxel-based chemotherapy.

G, Ploussard; S, Terry; P, Maillé; Y, Allory; N, Sirab; L, Kheuang; P, Soyeux; N, Nicolaiew; E, Coppolani; B, Paule; L, Salomon; S, Culine; R, Buttyan; F, Vacherot; la Taille A, de

doi:10.1158/0008-5472.can-10-1447

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Class III beta-tubulin expression predicts prostate tumor aggressiveness and patient response to docetaxel-based chemotherapy.

Shared by NobleBlocks on Nov 2, 2010 • 12:00 AM UTC

Authors:

Ploussard G

Terry S

Maillé P

Abstract

Expression of class III β-tubulin (βIII-tubulin) correlates with tumor progression and resistance to taxane-based therapies for several human malignancies, but its use as a biomarker of tumor behavior in prostate cancer (PCa) remains largely unexplored. Here, we describe βIII-tubulin immunohistochem...

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