Don′t shoot the messenger! An optical sensor for D-myo-inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), an intracellular second messenger, is constructed by introducing a fluorophore at a unique cysteine residue within a mutant of the pleckstrin homology (PH) domain of the general receptor for p...
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