Western diet induces dysbiosis with increased E coli in CEABAC10 mice , alters host barrier function favouring AIEC colonisation

Martínez-Medina, Margarita; Denizot, Jérémy; Dreux, Nicolas; Robin, Frédéric; Billard, Elisabeth; Bonnet, Richard; Darfeuille–Michaud, Arlette; Barnich, Nicolas

doi:10.1136/gutjnl-2012-304119

Public

Western diet induces dysbiosis with increased E coli in CEABAC10 mice , alters host barrier function favouring AIEC colonisation

Published in Gut • Apr 18, 2013

Authors:

Margarita Martínez-Medina

Jérémy Denizot

Nicolas Dreux

Abstract

OBJECTIVE: Western diet is a risk factor for Crohn's disease (CD). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is abnormally expressed in CD patients. This allows adherent-invasive Escherichia coli (AIEC) to colonise the gut mucosa and leads to inflammation. We assessed the e...

Subject

Biology

Dysbiosis

Microbiology

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!