Western diet induces dysbiosis with increased
                    <i>E coli</i>
                    in CEABAC10 mice
                    <i>,</i>
                    alters host barrier function favouring AIEC colonisation

Martinez-Medina, Margarita; Denizot, Jérémy; Dreux, Nicolas; Robin, Frédéric; Billard, Elisabeth; Bonnet, Richard; Darfeuille-Michaud, Arlette; Barnich, Nicolas

doi:10.1136/gutjnl-2012-304119

Public

Western diet induces dysbiosis with increased E coli in CEABAC10 mice , alters host barrier function favouring AIEC colonisation

Shared by NobleBlocks on Apr 18, 2013 • 12:00 AM UTC

Authors:

Margarita Martinez-Medina

Jérémy Denizot

Nicolas Dreux

Abstract

Objective Western diet is a risk factor for Crohn's disease (CD). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is abnormally expressed in CD patients. This allows adherent-invasive Escherichia coli (AIEC) to colonise the gut mucosa and leads to inflammation. We assessed the ef...

Discussions