Prospective Evaluation of the Effect of an Aminoglycoside Dosing Regimen on Rates of Observed Nephrotoxicity and Ototoxicity

J. Rybak, Michael; J. Abate, Betty; Kang, Sangrim; J. Ruffing, Michael; A. Lerner, Stephen; L. Drusano, George

doi:10.1128/aac.43.7.1549

Public

Prospective Evaluation of the Effect of an Aminoglycoside Dosing Regimen on Rates of Observed Nephrotoxicity and Ototoxicity

Published in Antimicrobial Agents and Chemotherapy • Jul 1, 1999

Authors:

Michael J. Rybak

Betty J. Abate

Sangrim Kang

Abstract

The nephrotoxicity and ototoxicity associated with once-daily versus twice-daily administration of aminoglycosides was assessed in patients with suspected or proven gram-negative bacterial infections in a randomized, double-blind clinical trial. Patients who received therapy for >/=72 h were evaluat...

Subject

Aminoglycoside

Medicine

Ototoxicity

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