Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

Meyer‐Luehmann, Melanie; Coomaraswamy, Janaky; Bolmont, Tristan; A. Kaeser, Stephan; Schaefer, Claudia; Kilger, Ellen; Neuenschwander, Anton; Abramowski, Dorothée; Frey, Pascal; L. Jaton, Anneliese; M. Vigouret, J.; Paganetti, Paolo; M. Walsh, Dominic; M. Mathews, Paul; Ghiso, Jorge; Staufenbiel, Matthias; C. Walker, Lary; Jucker, Mathias

doi:10.1126/science.1131864

Public

Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

Published in Science • Sep 21, 2006

Authors:

Melanie Meyer‐Luehmann

Janaky Coomaraswamy

Tristan Bolmont

Abstract

Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-beta (Abeta)-containing brain extracts from humans with Alzheimer's disease or beta-amyloid precursor protei...

Subject

Transgene

Amyloid (mycology)

Amyloidosis

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