A Novel Mucosal Vaccine Based on Live Lactococci Expressing E7 Antigen and IL-12 Induces Systemic and Mucosal Immune Responses and Protects Mice against Human Papillomavirus Type 16-Induced Tumors

G. Bermúdez‐Humarán, Luis; G. Cortes‐Perez, Naima; Lefèvre, François; Monteze Guimarães, Valéria; Rabot, Sylvie; Manuel Alcocer-González, Juan; Gratadoux, Jean‐Jacques; Rodrı́guez-Padilla, Cristina; S. Taméz-Guerra, Reyes; Corthier, Gérard; Gruss, Alexandra; Langella, Philippe

doi:10.4049/jimmunol.175.11.7297

Public

A Novel Mucosal Vaccine Based on Live Lactococci Expressing E7 Antigen and IL-12 Induces Systemic and Mucosal Immune Responses and Protects Mice against Human Papillomavirus Type 16-Induced Tumors

Published in The Journal of Immunology • Dec 1, 2005

Authors:

Luis G. Bermúdez‐Humarán

Naima G. Cortes‐Perez

François Lefèvre

Abstract

Current strategies to prevent or treat human papillomavirus type 16 (HPV-16) infection are promising, but remain costly. More economical but efficient vaccines are thus needed. In this study, we evaluated the protective effects of mucosally coadministered live Lactococcus lactis strains expressing c...

Subject

Immune system

Immunization

Vaccination

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