Common variants near MC4R are associated with fat mass, weight and risk of obesity

Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, The; J. F. Loos, Ruth; , KORA; Health Study, Nurses'; Genetics Initiative, Diabetes; SardiNIA Study, The; , FUSION; M. Lindgren, Cecilia; Li, Shengxu; Wheeler, Eleanor; Hua Zhao, Jing; Prokopenko, Inga; Inouye, Michael; M. Freathy, Rachel; Attwood, Antony; Beckmann, J.; I Berndt, Sonja; Bergmann, Sven; J. Bennett, Amanda; Bingham, Sheila; Bochud, Murielle; Brown, Morris; Cauchi, Stéphane; Connell, John; Cooper, Cyrus; Davey Smith, George; N.M. Day, Ian; Dina, Christian; De, Subhajyoti; T. Dermitzakis, Emmanouil; S. F. Doney, Alex; S. Elliott, Katherine; Elliott, Paul; M. Evans, David; Sadaf Farooqi, I.; Froguel, Philippe; Ghori, Jilur; J. Groves, Christopher; Gwilliam, Rhian; Hadley, David; S. Hall, Alistair; T. Hattersley, Andrew; Hebebrand, Johannes; M. Heid, Iris; Herrera, Blanca; Hinney, Anke; Hunt, Sarah; Järvelin, Marjo‐Riitta; Johnson, Toby; D M Jolley, Jennifer; Karpe, Fredrik; Keniry, Andrew; Khaw, Kay-Tee; Luben, Robert; Mangino, Massimo; Marchini, Jonathan; L. McArdle, Wendy; McGinnis, Ralph; Eyre, Stephen; B. Munroe, Patricia; D Morris, Andrew; R Ness, Andrew; Neville, Matthew; C. Nica, Alexandra; K. Ong, Ken; O’Rahilly, Stephen; R. Owen, Katharine; N A Palmer, Colin; A. Papadakis, Konstantinos; Potter, Simon; Pouta, Anneli; Qi, Lu; C. Randall, Joshua; W. Rayner, Nigel; M. Ring, Susan; S. Sandhu, Manjinder; Scherag, André; Sims, Matthew; Song, Kijoung; Soranzo, Nicole; K. Speliotes, Elizabeth; Syddall, Holly; A. Teichmann, Sarah; J. Timpson, Nicholas; H. Tobias, Jonathan; Uda, Manuela; Ivane Ganz Vogel, Carla; Wallace, Chris; Waterworth, Dawn; N. Weedon, Michael; J. Willer, Cristen; Wraight, Vicki; Yuan, Xin; Zeggini, Eleftheria; N. Hirschhorn, Joel; P. Strachan, David; H. Ouwehand, Willem; J. Caulfield, Mark; J. Samani, Nilesh; M. Frayling, Timothy; Vollenweider, Péter; Waeber, Gérard; Mooser, Vincent; Deloukas, Panos; I. McCarthy, Mark; J. Wareham, Nicholas; Barroso, Inês

doi:10.1038/ng.140

Public

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Published in Nature Genetics • May 4, 2008

Authors:

The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial

Ruth J. F. Loos

KORA

Abstract

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocort...

Subject

Biology

Obesity

Body mass index

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