Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits

Kristiansson, Kati; Perola, Markus; Tikkanen, Emmi; Kettunen, Johannes; Surakka, Ida; S. Havulinna, Aki; Stančáková, Alena; Barnes, Chris; Widen, Elisabeth; Kajantie, Eero; G. Eriksson, Johan; Viikari, Jorma; Kähönen, Mika; Lehtimäki, Terho; T. Raitakari, Olli; Hartikainen, Anna-Liisa; Ruokonen, Aimo; Pouta, Anneli; Jula, Antti; J. Kangas, Antti; Soininen, Pasi; Ala-Korpela, Mika; Männistö, Satu; Jousilahti, Pekka; L. Bonnycastle, Lori; Järvelin, Marjo-Riitta; Kuusisto, Johanna; S. Collins, Francis; Laakso, Markku; E. Hurles, Matthew; Palotie, Aarno; Peltonen, Leena; Ripatti, Samuli; Salomaa, Veikko

doi:10.1161/circgenetics.111.961482

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Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits

Shared by NobleBlocks on Apr 1, 2012 • 12:00 AM UTC

Authors:

Kati Kristiansson

Markus Perola

Emmi Tikkanen

Abstract

Background— Genome-wide association (GWA) studies have identified several susceptibility loci for metabolic syndrome (MetS) component traits, but have had variable success in identifying susceptibility loci to the syndrome as an entity. We conducted a GWA study on MetS and its component traits in 4 ...

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