Cellular Effect of High Doses of Silica-Coated Quantum Dot Profiled with High Throughput Gene Expression Analysis and High Content Cellomics Measurements

Zhang, Tingting; L. Stilwell, Jackie; Gerion, Daniele; Ding, Lianghao; Elboudwarej, Omeed; A. Cooke, Patrick; W. Gray, Joe; Paul Alivisatos, A.; Frank Chen, Fanqing

doi:10.1021/nl0603350

Public

Cellular Effect of High Doses of Silica-Coated Quantum Dot Profiled with High Throughput Gene Expression Analysis and High Content Cellomics Measurements

Published in Nano Letters • Apr 1, 2006

Authors:

Tingting Zhang

Jackie L. Stilwell

Daniele Gerion

Abstract

Quantum dots (Qdots) are now used extensively for labeling in biomedical research, and this use is predicted to grow because of their many advantages over alternative labeling methods. Uncoated Qdots made of core/shell CdSe/ZnS are toxic to cells because of the release of Cd2+ ions into the cellular...

Subject

Ethylene glycol

PEG ratio

Silane

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