CD4<b>+</b>CD25<b>+</b> regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

Ghiringhelli, François; Menard, Cédric; Terme, Magali; Flament, Caroline; Taı̈eb, Julien; Chaput, Nathalie; E. Puig, Pierre; Novault, Sophie; Escudier, Bernard; Vivier, Éric; Lecesne, A.; Robert, Caroline; Blay, Jean‐Yves; Bernard, Jacky; Caillat‐Zucman, Sophie; A. Freitas, António; Tursz, Thomas; Wagner‐Ballon, Orianne; Capron, Claude; Vainchencker, William; Martin, François; Zitvogel, Laurence

doi:10.1084/jem.20051511

Public

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

Published in The Journal of Experimental Medicine • Oct 17, 2005

Authors:

François Ghiringhelli

Cédric Menard

Magali Terme

Abstract

Tumor growth promotes the expansion of CD4+CD25+ regulatory T (T reg) cells that counteract T cell-mediated immune responses. An inverse correlation between natural killer (NK) cell activation and T reg cell expansion in tumor-bearing patients, shown here, prompted us to address the role of T reg ce...

Subject

Interleukin 21

NKG2D

IL-2 receptor

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