Accelerating Novel Candidate Gene Discovery in Neurogenetic Disorders via Whole-Exome Sequencing of Prescreened Multiplex Consanguineous Families

M. Alazami, Anas; Patel, Nisha; E. Shamseldin, Hanan; Anazi, Shamsa; S. Al‐Dosari, Mohammed; Alzahrani, Fatema; Hijazi, Hadia; Alshammari, Muneera; A. Aldahmesh, Mohammed; A. Salih, Mustafa; Faqeih, Eissa; Alhashem, Amal; A. Bashiri, Fahad; Al‐Owain, Mohammed; Y. Kentab, Amal; Sogaty, Sameera; Al Tala, Saeed; Temsah, Mohamad‐Hani; Tulbah, Maha; Aljelaify, Rasha; AlShahwan, Saad; Zain Seidahmed, Mohammed; A. Alhadid, Adnan; Aldhalaan, Hesham; AlQallaf, Fatema; Kurdi, Wesam; Alfadhel, Majid; Babay, Zainab; Alsogheer, Mohammad; Kaya, Namik; N. Al‐Hassnan, Zuhair; M. H. Abdel‐Salam, Ghada; Al‐Sannaa, Nouriya; Al Mutairi, Fuad; Y. El Khashab, Heba; Bohlega, Saeed; Jia, Xiaofei; C. Nguyen, Henry; Hammami, Rakad; Adly, Nouran; Y. Mohamed, Jawahir; Abdulwahab, Firdous; Ibrahim, Niema; A. Naim, Ewa; Al‐Younes, Banan; F. Meyer, Brian; Hashem, Mais; Shaheen, Ranad; Xiong, Yong; Abouelhoda, Mohamed; Aldeeri, Abdulrahman; Monies, Dorota; S. Alkuraya, Fowzan

doi:10.1016/j.celrep.2014.12.015

Public

Accelerating Novel Candidate Gene Discovery in Neurogenetic Disorders via Whole-Exome Sequencing of Prescreened Multiplex Consanguineous Families

Published in Cell Reports • Dec 31, 2014

Authors:

Anas M. Alazami

Nisha Patel

Hanan E. Shamseldin

Abstract

Our knowledge of disease genes in neurological disorders is incomplete. With the aim of closing this gap, we performed whole-exome sequencing on 143 multiplex consanguineous families in whom known disease genes had been excluded by autozygosity mapping and candidate gene analysis. This prescreening ...

Subject

Exome sequencing

Genetics

Candidate gene

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