Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice

We previously demonstrated the essential role of the flt-1 gene in regulating the development of the cardiovascular system. While the inactivation of the flt-1 gene leads to a very severe disorganization of the vascular system, the primary defect at the cellular level was unknown. Here we report a s... View More