Chronic Treatment with Interleukin-1β Attenuates Contractions by Decreasing the Activities of CPI-17 and MYPT-1 in Intestinal Smooth Muscle

Ohama, Takashi; Hori, Masatoshi; Sato, Koichi; Ozaki, Hiroshi; Karaki, Hideaki

doi:10.1074/jbc.m310166200

Public

Chronic Treatment with Interleukin-1β Attenuates Contractions by Decreasing the Activities of CPI-17 and MYPT-1 in Intestinal Smooth Muscle

Published in Journal of Biological Chemistry • Nov 26, 2003

Authors:

Takashi Ohama

Masatoshi Hori

Koichi Sato

Abstract

Interleukin-1β (IL-1β) is a proinflammatory cytokine that plays a central role in inflammatory bowel disease (IBD). In order to elucidate the mechanism of motility disorders frequently observed in IBD, we investigated the long term effects of IL-1β on rat ileal smooth muscle contractility by using a...

Subject

Smooth muscle

Medicine

Internal medicine

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