1,25-Dihydroxyvitamin D3 Differentially Regulates the Production of Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-4 in Mouse Osteoblasts*

Scharla, Stephan; D. Strong, Donna; Mohan, Subburaman; J. Baylink, David; A. Linkhart, Thomas

doi:10.1210/endo-129-6-3139

Public

1,25-Dihydroxyvitamin D3 Differentially Regulates the Production of Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-4 in Mouse Osteoblasts*

Published in Endocrinology • Dec 1, 1991

Authors:

Stephan Scharla

Donna D. Strong

Subburaman Mohan

Abstract

1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] induces differentiation and inhibits proliferation in many cell types including bone cells. These effects may be mediated by the modulation of the insulin-like growth factor (IGF) regulatory system. Therefore we investigated the effects of 1,25-(OH)2D3 on tran...

Subject

Endocrinology

Internal medicine

Insulin-like growth factor-binding protein

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