Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Woong Lee, Jae; Kyung Lee, Yong; Yeon Yuk, Dong; Young Choi, Dong; Bae Ban, Sang; Wan Oh, Ki; Tae Hong, Jin

doi:10.1186/1742-2094-5-37

Public

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Published in Journal of Neuroinflammation • Aug 29, 2008

Authors:

Jae Woong Lee

Yong Kyung Lee

Dong Yeon Yuk

Abstract

BACKGROUND: Alzheimer's disease (AD) is characterized by extensive loss of neurons in the brain of AD patients. Intracellular accumulation of beta-amyloid peptide (Abeta) has also shown to occur in AD. Neuro-inflammation has been known to play a role in the pathogenesis of AD. METHODS: In this study...

Subject

Inflammation

Lipopolysaccharide

In vivo

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