Molecular Markers for Failure of Sulfadoxine‐Pyrimethamine and Chlorproguanil‐Dapsone Treatment of <i>Plasmodium falciparum</i> Malaria

G. Kublin, James; K. Dzinjalamala, Fraction; Kamwendo, Deborah; Malkin, Elissa; F. Cortese, Joseph; M. Martino, Lisa; A. G. Mukadam, Rabia; J. Rogerson, Stephen; G. Lescano, Andrés; E. Molyneux, Malcolm; Winstanley, Peter; Chimpeni, Phillips; E. Taylor, Terrie; V. Plowe, Christopher

doi:10.1086/338566

Public

Molecular Markers for Failure of Sulfadoxine‐Pyrimethamine and Chlorproguanil‐Dapsone Treatment of Plasmodium falciparum Malaria

Published in The Journal of Infectious Diseases • Feb 1, 2002

Authors:

James G. Kublin

Fraction K. Dzinjalamala

Deborah Kamwendo

Abstract

Molecular assays for monitoring sulfadoxine-pyrimethamine-resistant Plasmodium falciparum have not been implemented because of the genetic and statistical complexity of the parasite mutations that confer resistance and their relation to treatment outcomes. This study analyzed pretreatment dihydrofol...

Subject

Plasmodium falciparum

Malaria

Sulfadoxine

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