Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

C. Villanueva, Eneida; Yalavarthi, Srilakshmi; C. Berthier, Céline; B. Hodgin, Jeffrey; Khandpur, Ritika; M. Lin, Andrew; J. Rubin, Cory; Zhao, Wenpu; H. Olsen, Stephen; W. Klinker, Matthew; J. Shealy, David; F. Denny, Michael; Plumas, Joël; Chaperot, Laurence; Kretzler, Matthias; T. Bruce, Allen; J. Kaplan, Mariana

doi:10.4049/jimmunol.1100450

Public

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

Published in The Journal of Immunology • May 26, 2011

Authors:

Eneida C. Villanueva

Srilakshmi Yalavarthi

Céline C. Berthier

Abstract

An abnormal neutrophil subset has been identified in the PBMC fractions from lupus patients. We have proposed that these low-density granulocytes (LDGs) play an important role in lupus pathogenesis by damaging endothelial cells and synthesizing increased levels of proinflammatory cytokines and type ...

Subject

Neutrophil extracellular traps

Systemic lupus erythematosus

Immunology

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