Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, Lijun; Wu, Jiaxi; Du, Fenghe; Chen, Xiang; J. Chen, Zhijian

doi:10.1126/science.1232458

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Shared by NobleBlocks on Feb 15, 2013 • 12:00 AM UTC

Authors:

Lijun Sun

Jiaxi Wu

Fenghe Du

Abstract

DNA Sensing Is a (c)GAS DNA is normally localized to the nucleus, and so its cytoplasmic localization sends off alarm bells to the immune system because it indicates that a virus may have entered. But how does the immune system actually detect the DNA (see the Perspective by O'Neill )? Sun et al. (p...

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