Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, Lijun; Wu, Jiaxi; Du, Fenghe; Chen, Xiang; J. Chen, Zhijian

doi:10.1126/science.1232458

Public

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Published in Science • Dec 21, 2012

Authors:

Lijun Sun

Jiaxi Wu

Fenghe Du

Abstract

The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), ...

Subject

IRF3

Stimulator of interferon genes

Interferon

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