Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity

C. Nucifora, Frederick; Sasaki, Masayuki; F. Peters, Matthew; Huang, Hui; K. Cooper, Jillian; Yamada, Mitsunori; Takahashi, Hitoshi; Tsuji, Shoji; C. Troncoso, Juan; L. Dawson, Valina; M. Dawson, Ted; A. Ross, Christopher

doi:10.1126/science.1056784

Public

Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity

Published in Science • Mar 23, 2001

Authors:

Frederick C. Nucifora

Masayuki Sasaki

Matthew F. Peters

Abstract

Expanded polyglutamine repeats have been proposed to cause neuronal degeneration in Huntington's disease (HD) and related disorders, through abnormal interactions with other proteins containing short polyglutamine tracts such as the transcriptional coactivator CREB binding protein, CBP. We found tha...

Subject

Huntingtin

Biology

Transcription factor

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!