p53 represses c-Myc through induction of the tumor suppressor <i>miR-145</i>

Sachdeva, Mohit; Zhu, Shoumin; Wu, Fangting; Wu, Hailong; Walia, Vijay; Kumar, Sumit; C. Elble, Randolph; Watabe, Kounosuke; Mo, Yin‐Yuan

doi:10.1073/pnas.0808042106

Public

p53 represses c-Myc through induction of the tumor suppressor miR-145

Published in Proceedings of the National Academy of Sciences • Feb 7, 2009

Authors:

Mohit Sachdeva

Shoumin Zhu

Fangting Wu

Abstract

The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may involve transcriptional regulation. However, it is not clear whether microRNAs (miRNAs) play a role ...

Subject

Psychological repression

Gene silencing

microRNA

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