Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

V. Scagliotti, Giorgio; Parikh, Purvish; von Pawel, Joachim; Biesma, Bonne; Vansteenkiste, Johan; Manegold, Christian; Serwatowski, Piotr; Gatzemeier, U.; Digumarti, Raghunadharao; Zukin, Mauro; S. Lee, Jin; Mellemgaard, Anders; Park, Keunchil; Patil, Shehkar; Rolski, Janusz; Göksel, Tuncay; de Marinis, Filippo; Simms, Lorinda; P. Sugarman, Katherine; R. Gandara, David

doi:10.1200/jco.2007.15.0375

Public

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

Published in Journal of Clinical Oncology • May 27, 2008

Authors:

Giorgio V. Scagliotti

Purvish Parikh

Joachim von Pawel

Abstract

PURPOSE: Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non-small-cell lung cancer (NSCLC). Phase II studies of pemetrexed plus platinum compounds have also shown activity in this setting. PATIENTS AND METHODS: This noninferiority, phase III, randomized study c...

Subject

Pemetrexed

Gemcitabine

Medicine

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