Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

Goldbach‐Mansky, Raphaela; Dailey Garnes, Natalie; Canna, Scott; Gelabert, A; H. Jones, Janet; I. Rubin, Benjamin; Jeffrey Kim, H.; C. Brewer, Carmen; Zalewski, Christopher; Wiggs, Edythe; Hill, Suvimol; L. Turner, Maria; I. Karp, Barbara; Aksentijevich, Ivona; Pucino, Frank; Penzak, Scott; H. Haverkamp, Margje; D. Stein, Leonard; S. Adams, Barbara; L. Moore, Terry; C. Fuhlbrigge, Robert; Shaham, Bracha; N. Jarvis, James; M. O’Neil, Kathleen; K. Vehe, Richard; Beitz, Laurie; C. Gardner, Gregory; P. Hannan, William; W. Warren, Robert; Horn, William; L. Cole, Joe; M. Paul, Scott; N. Hawkins, Philip; Pham, Tuyet; S. Snyder, Christopher; Wesley, Robert; C. Hoffmann, Steven; M. Holland, Steven; A. Butman, John; L. Kastner, Daniel

doi:10.1056/nejmoa055137

Public

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

Published in New England Journal of Medicine • Aug 9, 2006

Authors:

Raphaela Goldbach‐Mansky

Natalie Dailey Garnes

Scott Canna

Abstract

BACKGROUND: Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation. Many patients have mutations in the cold-induced autoinflammatory syndrome 1 (CIAS1) gene, encoding cryopyrin, a pr...

Subject

Anakinra

Medicine

Erythrocyte sedimentation rate

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