DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations

Sharma, Amit; Ahmer Jamil, Muhammad; Nuesgen, Nicole; Schreiner, Felix; Priebe, Lutz; Hoffmann, Per; Herns, Stefan; M. Nöthen, Markus; Fröhlich, Holger; Oldenburg, Johannes; Woelfle, Joachim; El‐Maarri, Osman

doi:10.1186/s13148-015-0112-2

Public

DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations

Published in Clinical Epigenetics • Jul 27, 2015

Authors:

Amit Sharma

Muhammad Ahmer Jamil

Nicole Nuesgen

Abstract

BACKGROUND: Abnormal sex chromosome numbers in humans are observed in Turner (45,X) and Klinefelter (47,XXY) syndromes. Both syndromes are associated with several clinical phenotypes, whose molecular mechanisms are obscure, and show a range of inter-individual penetrance. In order to understand the ...

Subject

Human genetics

Peripheral blood

DNA methylation

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