Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase–deficient (MME −/− ) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME − / − mice did not have increased numbers of macrophages in their lungs a... View More