Short-Course Rifampin and Pyrazinamide Compared with Isoniazid for Latent Tuberculosis Infection: A Multicenter Clinical Trial

M. Jasmer, Robert; Saukkonen, Jussi; M. Blumberg, Henry; L. Daley, Charles; Bernardo, John; Vittinghoff, Eric; D. King, Mark; Masae Kawamura, L.; C. Hopewell, Philip; the Short-Course Rifampin and Pyrazinamide for Tuberculosis Infection (SCRIPT) Study Investigators*, for

doi:10.7326/0003-4819-137-8-200210150-00007

Public

Short-Course Rifampin and Pyrazinamide Compared with Isoniazid for Latent Tuberculosis Infection: A Multicenter Clinical Trial

Published in Annals of Internal Medicine • Oct 15, 2002

Authors:

Robert M. Jasmer

Jussi Saukkonen

Henry M. Blumberg

Abstract

BACKGROUND: Rifampin and pyrazinamide are recommended for treatment of latent tuberculosis infection in adults without HIV infection, but reports of severe hepatotoxicity have raised concerns about its safety. Clinical trials have not compared this treatment with isoniazid in adults without HIV infe...

Subject

Pyrazinamide

Medicine

Isoniazid

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