Preclinical Evaluation of an Anti-Autocrine Growth Factor Monoclonal Antibody for Treatment of Patients With Small-Cell Lung Cancer

Avis, Ingallil; O. G. Kovacs, T.; G. Kasprzyk, Philip; M. Treston, Anthony; M. Bartholomew, Richard; H. Walsh, John; Cuttitta, Frank; L. Mulshine, James

doi:10.1093/jnci/83.20.1470

Public

Preclinical Evaluation of an Anti-Autocrine Growth Factor Monoclonal Antibody for Treatment of Patients With Small-Cell Lung Cancer

Published in JNCI Journal of the National Cancer Institute • Oct 16, 1991

Authors:

Ingallil Avis

T. O. G. Kovacs

Philip G. Kasprzyk

Abstract

We have evaluated an anti-autocrine growth factor monoclonal antibody for potential use in the treatment of patients with small-cell lung cancer. The monoclonal antibody, designated 2A11, binds to the C-terminal region of the autocrine growth factor gastrin-releasing peptide and neutralizes its grow...

Subject

Autocrine signalling

Bombesin

Gastrin-releasing peptide

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