Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis

Kiryluk, Krzysztof; Li, Yifu; Sanna‐Cherchi, Simone; Rohanizadegan, Mersedeh; Suzuki, Hitoshi; Eitner, Frank; J. Snyder, Holly; Choi, Murim; Hou, Ping; Scolari, Francesco; Izzi, Claudia; Gigante, Maddalena; Gesualdo, Loreto; Savoldi, Silvana; Amoroso, Antonio; Cusi, Daniele; Zamboli, Pasquale; A. Julian, Bruce; Novák, Jan; Wyatt, Robert; Mucha, Krzysztof; Perola, Markus; Kristiansson, Kati; Viktorin, Alexander; K. E. Magnusson, Patrik; Þorleifsson, Guðmar; Þorsteinsdóttir, Unnur; Stefánsson, Kāri; Boland, Anne; Metzger, Marie; Thibaudin, Lise; Wanner, Christoph; J. Jager, Kitty; Goto, Shin; Maixnerová, Dita; H. Karnib, Hussein; Nagy, Judit; Panzer, Ulf; Xie, Jingyuan; Chen, Nan; Tesař, Vladimı́r; Narita, Ichiei; Berthoux, F.; Floege, Jürgen; Stengel, Bénédicte; Zhang, Hong; P. Lifton, Richard; G. Gharavi, Ali

doi:10.1371/journal.pgen.1002765

Public

Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis

Published in PLoS Genetics • Jun 21, 2012

Authors:

Krzysztof Kiryluk

Yifu Li

Simone Sanna‐Cherchi

Abstract

IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians, moderately prevalent in Europeans, and rare in Africans. It is not known if these differences represent variation in genes, environment, or ascertainment. In a recent GWAS, we localized five IgAN susceptibility loc...

Subject

Biology

Genome-wide association study

Genetics

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