Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients

Romano, Emanuela; Kusio-Kobialka, Monika; G. Foukas, Periklis; Baumgaertner, Petra; Meyer, Christiane; Ballabeni, Pierluigi; Michielin, Olivier; Weide, Benjamin; Romero, Pedro; E. Speiser, Daniel

doi:10.1073/pnas.1417320112

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Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients

Shared by NobleBlocks on Apr 27, 2015 • 12:00 AM UTC

Authors:

Emanuela Romano

Monika Kusio-Kobialka

Periklis G. Foukas

Abstract

Significance mAbs directed to inhibitory immune receptors represent a very promising class of immunotherapeutics. This study suggests a potential mechanism of action of ipilimumab (a fully human anti–cytotoxic T lymphocyte–associated antigen 4), by which FcγRIIIA (CD16)-expressing nonclassical monoc...

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