Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Bien‐Ly, Nga; Yu, Yang; Bumbaca, Daniela; Elstrott, Justin; Andrew Boswell, C.; Zhang, Yin; Luk, Wilman; Lu, Yanmei; S. Dennis, Mark; M. Weimer, Robby; Chung, Inhee; J. Watts, Ryan

doi:10.1084/jem.20131660

Public

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Published in The Journal of Experimental Medicine • Jan 27, 2014

Authors:

Nga Bien‐Ly

Yang Yu

Daniela Bumbaca

Abstract

Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and β-secretase (BACE1 [β-amyloid cleaving enzyme-1]) traverse the blood-brain barrier (BBB) and effectively reduce brain amyloid β levels. We found ...

Subject

Transferrin receptor

Transcytosis

Antibody

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!