Impairment of paravascular clearance pathways in the aging brain

T. Kress, Benjamin; J. Iliff, Jeffrey; Xia, Maosheng; Wang, Minghuan; Wei, Helen; Zeppenfeld, Douglas; Xie, Lulu; Kang, Hongyi; Xu, Qiwu; Liew, Jason; A. Plog, Benjamin; Ding, Fengfei; Deane, Rashid; Nedergaard, Maiken

doi:10.1002/ana.24271

Public

Impairment of paravascular clearance pathways in the aging brain

Published in Annals of Neurology • Sep 10, 2014

Authors:

Benjamin T. Kress

Jeffrey J. Iliff

Maosheng Xia

Abstract

OBJECTIVE: In the brain, protein waste removal is partly performed by paravascular pathways that facilitate convective exchange of water and soluble contents between cerebrospinal fluid (CSF) and interstitial fluid (ISF). Several lines of evidence suggest that bulk flow drainage via the glymphatic s...

Subject

Glymphatic system

Interstitial fluid

Cerebrospinal fluid

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