The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.

F, Fuks; PJ, Hurd; D, Wolf; X, Nan; AP, Bird; T, Kouzarides

doi:10.1074/jbc.m210256200

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The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.

Shared by NobleBlocks on Nov 9, 2002 • 12:00 AM UTC

Authors:

Fuks F

Hurd PJ

Wolf D

Abstract

DNA methylation plays an important role in mammalian development and correlates with chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG dinucleotides represents a major mechanism by which DNA methylation can repress transcription. MeCP2 silences gene expression partly by...

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