BMS-777607, a Small-Molecule Met Kinase Inhibitor, Suppresses Hepatocyte Growth Factor–Stimulated Prostate Cancer Metastatic Phenotype <i>In vitro</i>

Dai, Yao; W. Siemann, Dietmar

doi:10.1158/1535-7163.mct-10-0359

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BMS-777607, a Small-Molecule Met Kinase Inhibitor, Suppresses Hepatocyte Growth Factor–Stimulated Prostate Cancer Metastatic Phenotype In vitro

Published in Molecular Cancer Therapeutics • Jun 1, 2010

Authors:

Yao Dai

Dietmar W. Siemann

Abstract

Most prostate cancer-related deaths are due to advanced disease with patients with metastatic prostate cancer having a 5-year survival rate of only 34%. Overexpression of c-Met receptor tyrosine kinase has been highly associated with prostate cancer progression and metastasis. In the present studies...

Subject

DU145

Hepatocyte growth factor

Cancer research

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