Meta-Analysis of Genome-Wide Association Studies in &gt;80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

Dehghan, Abbas; Dupuis, Josée; Barbalić, Maja; C. Bis, Joshua; Eiríksdóttir, Guðný; Chen, Lu; Pellikka, Niina; Wallaschofski, Henri; Kettunen, Johannes; Henneman, Peter; Baumert, Jens; P. Strachan, David; Fuchsberger, Christian; Vitart, Véronique; F. Wilson, James; Paré, Guillaume; Naitza, Silvia; E. Rudock, Megan; Surakka, Ida; J. C. de Geus, Eco; Z. Alizadeh, Behrooz; M. Guralnik, Jack; R. Shuldiner, Alan; Tanaka, Toshiko; Y.L. Zee, Robert; B. Schnabel, Renate; Nambi, Vijay; Kavousi, Maryam; Ripatti, Samuli; Nauck, Matthias; L. Smith, Nicholas; V. Smith, Albert; Sundvall, Jouko; Scheet, Paul; Liu, Ching‐Ti; Ruokonen, Aimo; M. Rose, Lynda; G. Larson, Martin; C. Hoogeveen, Ron; B. Freimer, Nelson; Teumer, Alexander; P. Tracy, Russell; J. Launer, Lenore; E. Buring, Julie; F. Yamamoto, Jennifer; R. Folsom, Aaron; J.G. Sijbrands, Eric; S. Pankow, James; Elliott, Paul; F. Keaney, John; Sun, Wei; Sarin, Antti-Pekka; D. Fontes, João; Badola, Sunita; C. Astor, Brad; Hofman, Albert; Pouta, Anneli; Werdan, Karl; Halina Greiser, Karin; Kuß, Oliver; E. Meyer zu Schwabedissen, Henriette; Thiery, Joachim; Jamshidi, Yalda; M. Nolte, Ilja; Soranzo, Nicole; D. Spector, Timothy; Völzke, Henry; N. Parker, Alexander; Aspelund, Thor; O. Bates, David; Young, Lauren; Tsui, Kim; S. Siscovick, David; Guo, Xiuqing; I. Rotter, Jerome; Uda, Manuela; Schlessinger, David; Rudan, Igor; A. Hicks, Andrew; W.J.H. Penninx, Brenda; Thorand, Barbara; Gieger, Christian; Coresh, Joe; Willemsen, Gonneke; B. Harris, Tamara; G. Uitterlinden, André; Järvelin, Marjo‐Riitta; Rice, Kenneth; Radke, Dörte; Salomaa, Veikko; Willems van Dijk, Ko; Boerwinkle, Eric; S. Vasan, Ramachandran; Ferrucci, Luigi; Gibson, Quince; Bandinelli, Stefania; Snieder, Harold; I. Boomsma, Dorret; Xiao, Xiangjun; Campbell, Harry; Hayward, Caroline; P. Pramstaller, Peter; M. van Duijn, Cornelia; Peltonen, Leena; M. Psaty, Bruce; Guðnason, Vilmundur; M. Ridker, Paul; Homuth, Georg; Köenig, Wolfgang; M. Ballantyne, Christie; C.M. Witteman, Jacqueline; J. Benjamin, Emelia; Perola, Markus; I. Chasman, Daniel

doi:10.1161/circulationaha.110.948570

Public

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

Published in Circulation • Feb 8, 2011

Authors:

Abbas Dehghan

Josée Dupuis

Maja Barbalić

Abstract

BACKGROUND: C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels. METHODS AND RESULTS: We performed a genome-wide association analysis of CRP in 66 18...

Subject

Genome-wide association study

Genetics

Genetic association

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