A Segment of γ ENaC Mediates Elastase Activation of Na+ Transport

Adebamiro, Adedotun; Cheng, Yi; Subrahmanyeswara Rao, U.; Danahay, Henry; J. Bridges, Robert

doi:10.1085/jgp.200709781

Public

A Segment of γ ENaC Mediates Elastase Activation of Na+ Transport

Published in The Journal of General Physiology • Nov 12, 2007

Authors:

Adedotun Adebamiro

Yi Cheng

U. Subrahmanyeswara Rao

Abstract

The epithelial Na(+) channel (ENaC) that mediates regulated Na(+) reabsorption by epithelial cells in the kidney and lungs can be activated by endogenous proteases such as channel activating protease 1 and exogenous proteases such as trypsin and neutrophil elastase (NE). The mechanism by which exoge...

Subject

Epithelial sodium channel

Proteases

Aprotinin

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