BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.

J Whittle, Andrew; Carobbio, Stefania; Martins, Luís; Slawik, Marc; Hondares, Elayne; Jesús Vázquez, María; Morgan, Donald; I Csikasz, Robert; Gallego, Rosalía; Rodriguez-Cuenca, Sergio; Dale, Martin; Virtue, Samuel; Villarroya, Francesc; Cannon, Barbara; Rahmouni, Kamal; López, Miguel; Vidal-Puig, Antonio

doi:10.1016/j.cell.2012.02.066

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BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.

Shared by NobleBlocks on May 11, 2012 • 12:00 AM UTC

Authors:

Andrew J Whittle

Stefania Carobbio

Luís Martins

Abstract

Thermogenesis in brown adipose tissue (BAT) is fundamental to energy balance and is also relevant for humans. Bone morphogenetic proteins (BMPs) regulate adipogenesis, and, here, we describe a role for BMP8B in the direct regulation of thermogenesis. BMP8B is induced by nutritional and thermogenic f...

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