HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

Mielcarek, Michał; Landles, Christian; Weiss, Andreas; Bradaïa, Amyaouch; Seredenina, Tamara; Inuabasi, Linda; F Osborne, Georgina; Wadel, Kristian; Touller, Chrystelle; Butler, Rachel; Robertson, Janette; Franklin, Sophie; L. Smith, Donna; Park, Larry; A. Marks, Paul; E. Wanker, Erich; N. Olson, Eric; Luthi‐Carter, Ruth; van der Putten, Herman; Beaumont, Vahri; P. Bates, Gillian

doi:10.1371/journal.pbio.1001717

Public

HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

Published in PLoS Biology • Nov 26, 2013

Authors:

Michał Mielcarek

Christian Landles

Andreas Weiss

Abstract

Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion i...

Subject

Biology

Neurodegeneration

Huntingtin

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