Tolerability, pharmacokinetics and pharmacodynamics of <scp>TA</scp>‐8995, a selective cholesteryl ester transfer protein (<scp>CETP</scp>) inhibitor, in healthy subjects

Ford, J.; Lawson, Matt; E. Fowler, D.; Maruyama, Nobuko; Mito, Seiji; Tomiyasu, Koichi; Kinoshita, Shuji; Suzuki, Chisa; Kawaguchi, Atsuhiro; Round, Patrick; Boyce, Malcolm; Warrington, Steve; Weber, Werner; van Deventer, Sander; J.P. Kastelein, John

doi:10.1111/bcp.12380

Public

Tolerability, pharmacokinetics and pharmacodynamics of TA‐8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects

Published in British Journal of Clinical Pharmacology • Mar 17, 2014

Authors:

J. Ford

Matt Lawson

D. E. Fowler

Abstract

AIMS: Two double-blind, randomized studies were conducted to assess the tolerability, pharmacokinetics and pharmacodynamics of oral TA-8995, a new cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. METHODS: Study 1: Subjects received single doses of TA-8995 or placebo (fasted)...

Subject

Tolerability

Pharmacokinetics

Cholesterylester transfer protein

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