Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

Yoneyama, Mitsutoshi; Kikuchi, Mika; Matsumoto, Kanae; Imaizumi, Tadaatsu; Miyagishi, Makoto; Taira, Kazunari; Foy, Eileen; Loo, Yueh-Ming; Gale, Michael; Akira, Shizuo; Yonehara, Shin; Kato, Atsushi; Fujita, Takashi

doi:10.4049/jimmunol.175.5.2851

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Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

Shared by NobleBlocks on Sep 1, 2005 • 12:00 AM UTC

Authors:

Mitsutoshi Yoneyama

Mika Kikuchi

Kanae Matsumoto

Abstract

Abstract The cellular protein retinoic acid-inducible gene I (RIG-I) senses intracellular viral infection and triggers a signal for innate antiviral responses including the production of type I IFN. RIG-I contains a domain that belongs to a DExD/H-box helicase family and exhibits an N-terminal caspa...

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