Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

V, Escott-Price; C, Bellenguez; LS, Wang; SH, Choi; D, Harold; L, Jones; P, Holmans; A, Gerrish; A, Vedernikov; A, Richards; AL, DeStefano; JC, Lambert; CA, Ibrahim-Verbaas; AC, Naj; R, Sims; G, Jun; JC, Bis; GW, Beecham; B, Grenier-Boley; G, Russo; TA, Thornton-Wells; N, Denning; AV, Smith; V, Chouraki; C, Thomas; MA, Ikram; D, Zelenika; BN, Vardarajan; Y, Kamatani; CF, Lin; H, Schmidt; B, Kunkle; ML, Dunstan; M, Vronskaya; AD, Johnson; A, Ruiz; MT, Bihoreau; C, Reitz; F, Pasquier; P, Hollingworth; O, Hanon; AL, Fitzpatrick; JD, Buxbaum; D, Campion; PK, Crane; C, Baldwin; T, Becker; V, Gudnason; C, Cruchaga; D, Craig; N, Amin; C, Berr; OL, Lopez; Jager PL, De; V, Deramecourt; JA, Johnston; D, Evans; S, Lovestone; L, Letenneur; I, Hernández; DC, Rubinsztein; G, Eiriksdottir; K, Sleegers; AM, Goate; N, Fiévet; MJ, Huentelman; M, Gill; K, Brown; MI, Kamboh; L, Keller; P, Barberger-Gateau; B, McGuinness; EB, Larson; AJ, Myers; C, Dufouil; S, Todd; D, Wallon; S, Love; E, Rogaeva; J, Gallacher; PS, George-Hyslop; J, Clarimon; A, Lleo; A, Bayer; DW, Tsuang; L, Yu; M, Tsolaki; P, Bossù; G, Spalletta; P, Proitsi; J, Collinge; S, Sorbi; FS, Garcia; NC, Fox; J, Hardy; MC, Naranjo; P, Bosco; R, Clarke; C, Brayne; D, Galimberti; E, Scarpini; U, Bonuccelli; M, Mancuso; G, Siciliano; S, Moebus; P, Mecocci; MD, Zompo; W, Maier; H, Hampel; A, Pilotto; A, Frank-García; F, Panza; V, Solfrizzi; P, Caffarra; B, Nacmias; W, Perry; M, Mayhaus; L, Lannfelt; H, Hakonarson; S, Pichler; MM, Carrasquillo; M, Ingelsson; D, Beekly; V, Alvarez; F, Zou; O, Valladares; SG, Younkin; E, Coto; KL, Hamilton-Nelson; W, Gu; C, Razquin; P, Pastor; I, Mateo; MJ, Owen; KM, Faber; PV, Jonsson; O, Combarros; MC, O'Donovan; LB, Cantwell; H, Soininen; D, Blacker; S, Mead; TH Jr, Mosley; DA, Bennett; TB, Harris; L, Fratiglioni; C, Holmes; Bruijn RF, de; P, Passmore; TJ, Montine; K, Bettens; JI, Rotter; A, Brice; K, Morgan; TM, Foroud; WA, Kukull; D, Hannequin; JF, Powell; MA, Nalls; K, Ritchie; KL, Lunetta; JS, Kauwe; E, Boerwinkle; M, Riemenschneider; M, Boada; M, Hiltunen; ER, Martin; R, Schmidt; D, Rujescu; JF, Dartigues; R, Mayeux; C, Tzourio; A, Hofman; MM, Nöthen; C, Graff; BM, Psaty; JL, Haines; M, Lathrop; MA, Pericak-Vance; LJ, Launer; Broeckhoven C, Van; LA, Farrer; Duijn CM, van; A, Ramirez; S, Seshadri; GD, Schellenberg; P, Amouyel; J, Williams

doi:10.1371/journal.pone.0094661

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Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

Shared by NobleBlocks on Jun 12, 2014 • 12:00 AM UTC

Authors:

Escott-Price V

Bellenguez C

Wang LS

Abstract

Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach whi...

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