Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

A, Lai; S, Kharbanda; WB, Pope; A, Tran; OE, Solis; F, Peale; WF, Forrest; K, Pujara; JA, Carrillo; A, Pandita; BM, Ellingson; CW, Bowers; RH, Soriano; NO, Schmidt; S, Mohan; WH, Yong; S, Seshagiri; Z, Modrusan; Z, Jiang; KD, Aldape; PS, Mischel; LM, Liau; CJ, Escovedo; W, Chen; PL, Nghiemphu; CD, James; MD, Prados; M, Westphal; K, Lamszus; T, Cloughesy; HS, Phillips

doi:10.1200/jco.2010.33.8715

Public

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

Shared by NobleBlocks on Oct 24, 2011 • 12:00 AM UTC

Authors:

Lai A

Kharbanda S

Pope WB

Abstract

Purpose Mutation in isocitrate dehydrogenase 1 (IDH1) at R132 (IDH1(R132MUT)) is frequent in low-grade diffuse gliomas and, within glioblastoma (GBM), has been proposed as a marker for GBMs that arise by transformation from lower-grade gliomas, regardless of clinical history. To determine how GBMs a...

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