A <i>Toxoplasma</i> dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

Braun, Laurence; Brenier‐Pinchart, Marie‐Pierre; Yogavel, M.; Curt-Varesano, Aurélie; Curt-Bertini, Rose-Laurence; Hussain, Tahir; Kieffer‐Jaquinod, Sylvie; Couté, Yohann; Pelloux, Hervé; Tardieux, Isabelle; Sharma, Amit; Belrhali, Hassan; Bougdour, Alexandre; Hakimi, Mohamed‐Ali

doi:10.1084/jem.20130103

Public

A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

Published in The Journal of Experimental Medicine • Sep 16, 2013

Authors:

Laurence Braun

Marie‐Pierre Brenier‐Pinchart

M. Yogavel

Abstract

Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, Toxoplasma actively remodels the transcriptome of its hosting cells with profound and coupled impact on the host immune response. ...

Subject

Cell biology

Toxoplasma gondii

Biology

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