Safety of Chronic Intrathecal Morphine Infusion in a Sheep Model

Lee Gradert, Tamara; B. Baze, Wallace; C. Satterfield, William; R. Hildebrand, Keith; Johansen, Mary; J. Hassenbusch, Samuel

doi:10.1097/00000542-200307000-00029

Public

Safety of Chronic Intrathecal Morphine Infusion in a Sheep Model

Published in Anesthesiology • Jul 1, 2003

Authors:

Tamara Lee Gradert

Wallace B. Baze

William C. Satterfield

Abstract

BACKGROUND: The safety of chronically administered intrathecal morphine has been questioned. Therefore, the authors examined the behavioral and neurologic effects and neurotoxicity of continuous intrathecal morphine administration in sheep. METHODS: Groups of three sheep were implanted with intrathe...

Subject

Medicine

Morphine

Spinal cord

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