Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype

M.J. Hanssen, Nordin; Wouters, Kristiaan; Huijberts, M.; J. Gijbels, Marion; C. Sluimer, Judith; L.J.M. Scheijen, Jean; Heeneman, Sylvia; A.L. Biessen, Erik; J.A.P. Daemen, Mat; Brownlee, Michael; PV de Kleijn, Dominique; D.A. Stehouwer, Coen; Pasterkamp, Gerard; G. Schalkwijk, Casper

doi:10.1093/eurheartj/eht402

Public

Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype

Published in European Heart Journal • Oct 14, 2013

Authors:

Nordin M.J. Hanssen

Kristiaan Wouters

M. Huijberts

Abstract

AIMS: Rupture-prone atherosclerotic plaques are characterized by inflammation and a large necrotic core. Inflammation is linked to high metabolic activity. Advanced glycation endproducts (AGEs) and their major precursor methylglyoxal are formed during high metabolic activity and can have detrimental...

Subject

Methylglyoxal

Medicine

Inflammation

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