RNA recognition by human TLR8 can lead to autoimmune inflammation

Guiducci, Cristiana; Gong, Mei; Cepika, Alma‐Martina; Xu, Zhaohui; Tripodo, Claudio; Bennett, Lynda; Crain, Chad; Quartier, Pierre; J. Cush, John; Pascual, Virginia; L. Coffman, Robert; J. Barrat, Franck

doi:10.1084/jem.20131044

Public

RNA recognition by human TLR8 can lead to autoimmune inflammation

Published in The Journal of Experimental Medicine • Nov 25, 2013

Authors:

Cristiana Guiducci

Mei Gong

Alma‐Martina Cepika

Abstract

Studies on the role of the RNA receptor TLR8 in inflammation have been limited by its different function in human versus rodents. We have generated multiple lines of transgenic mice expressing different levels of human TLR8. The high copy number chimeras were unable to pass germline; developed sever...

Subject

Inflammation

Proinflammatory cytokine

Immunology

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