Initial genome sequencing and analysis of multiple myeloma

A. Chapman, Michael; S. Lawrence, Michael; J. Keats, Jonathan; Cibulskis, Kristian; Sougnez, Carrie; C. Schinzel, Anna; L. Harview, Christina; Brunet, Jean-Philippe; Ahmann, Gregory; Adli, Mazhar; C. Anderson, Kenneth; Ardlie, Kristin; Auclair, Daniel; Baker, Angela; Leif Bergsagel, P.; Bernstein, B; Drier, Yotam; Fonseca, Rafaël; Gabriel, Stacey; C. Hofmeister, Craig; Jagannath, Sundar; Jakubowiak, Andrzej; Krishnan, Amrita; Levy, Joan; Liefeld, Ted; Lonial, Sagar; Mahan, Scott; Mfuko, Bunmi; Monti, Stefano; M. Perkins, Louise; Onofrio, Robb; J. Pugh, Trevor; Vincent Rajkumar, S.; H. Ramos, Alex; S. Siegel, David; Sivachenko, Andrey; Keith Stewart, A.; Trudel, Suzanne; Vij, Ravi; Voet, Douglas; Winckler, Wendy; M. Zimmerman, Todd; D. Carpten, John; Trent, J.M.; C. Hahn, William; A. Garraway, Levi; Meyerson, Matthew; S. Lander, Eric; Getz, Gad; R. Golub, Todd

doi:10.1038/nature09837

Public

Initial genome sequencing and analysis of multiple myeloma

Published in Nature • Mar 1, 2011

Authors:

Michael A. Chapman

Michael S. Lawrence

Jonathan J. Keats

Abstract

Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. Several new and unexpected oncogenic mechanisms were suggested by the pattern of ...

Subject

Biology

Multiple myeloma

Gene

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