Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids

Almeida, Maria; Han, Li; Martín-Millán, Marta; I. Plotkin, Lilian; Stewart, Scott; K. Roberson, Paula; Kousteni, Stavroula; A. O’Brien, Charles; Bellido, Teresita; M. Parfitt, A.; S. Weinstein, Robert; L. Jilka, Robert; C. Manolagas, Stavros

doi:10.1074/jbc.m702810200

Public

Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids

Published in Journal of Biological Chemistry • Jul 11, 2007

Authors:

Maria Almeida

Li Han

Marta Martín-Millán

Abstract

Both aging and loss of sex steroids have adverse effects on skeletal homeostasis, but whether and how they may influence each others negative impact on bone remains unknown. We report herein that both female and male C57BL/6 mice progressively lost strength (as determined by load-to-failure measurem...

Subject

Endocrinology

Oxidative stress

Internal medicine

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